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In patients with severe liver disease, portal blood bypassing the liver leads to increased levels of ammonia and other toxic substances in the blood, which can lead to complications such as brain damage, sarcopenia and muscle spasticity [204]

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You can read the abstract of this article at The idea of Reward Deficiency Syndrome suggests that addiction to various substances occurs because they stimulate the brains reward system so intensely that the population of dopamine D2 receptors (DD2R) decreases