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It also reduces hunger and stomach emptying, leading to lower food intake

Levels of the target metabolic substances were calculated from the peak area, by using mass chromatography and indicated as relative amounts following normalization using the internal standard (d-camphor-10-sulfonic acid) peak area

Several genetic variants influence these pathways, including the GLP1R gene and the MC4R gene, which affects satiety signaling

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Mono-genetic diseases affecting the hypothalamic appetite center may cause early onset of massive obesity [3]