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The GSH-mediated regulation of ferroptosis has shown some promising results in the treatment of ischemic injury to the liver, kidney, brain, and heart as well as some neurodegenerative diseases [18]

Rare adverse events may therefore go undetected

By delivering therapeutic agents like siRNA that targets IB, MnNPs can effectively trigger the NF-B signaling pathway in these macrophages, repolarizing them from a tumor-promoting M2 phenotype to a tumor-fighting M1 phenotype

( E ) Violin plot showing the expressions of 11 immune checkpoint points in GSE178318

intravenous administration of glutathione are generally not practical for increasing circulating glutathione for most individuals because this procedure is expensive, requires regular visits to a medical practitioner's office, is unsuitable for children and many adults, and poses the risks of side effects associated with regular injections