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Furthermore, research has shown that chronic lack of sleep may decrease glutathione levels

What is an Antioxidant

Metformin and liraglutide ameliorate high glucose-induced oxidative stress via inhibition of PKC-NAD(P)H oxidase pathway in human aortic endothelial cells

This suggests that underlying health conditions, including obesity, longer duration of diabetes, and cardiovascular disease, may have contributed to the observed association

In general, phase I metabolizing enzymes catalyze reactions that increase the reactivity of hydrophobic (fat-soluble) compounds, preparing them for reactions catalyzed by phase II biotransformation enzymes