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Ethics Ethics Committee Approval: This research was authorized by the Maltepe University Animal Experiments Local Ethics Committee (approval no: 2023.06.03, date: 29.06.2023)
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R Clinical genetics resources: PharmGKB (pharmacogenomics knowledge base): pharmgkb.org CPIC (Clinical Pharmacogenetics Implementation Consortium) guidelines for UGT1A1, NAT2, TPMT: cpicpgx.org Conjugation pathway substrates and testing: The Hepatic Detox Profile (caffeine/aspirin/acetaminophen challenge) is the gold standard functional test for Phase I/II conjugation capacity in clinical practice
Metformin improves mitochondrial respiratory activity through activation of AMPK
It is produced naturally in the liver and plays several vital roles in the body
