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Glutathione levels decline roughly 1015% per decade after age 20, which makes IV supplementation increasingly relevant with age

Diabetes Obes Metab 9:869878 Ahren B, Foley JE, Ferrannini E et al (2010) Changes in prandial glucagon levels after a 2-year treatment with vildagliptin or glimepiride in patients with type 2 diabetes inadequately controlled with metformin monotherapy