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In a transgenic mouse model of mutant alpha-synuclein (A53T), experiments showed that alpha-synuclein accumulation in astrocytes affected glutamate transport, triggering a rise of extracellular glutamatergic concentrations and excitotoxicity, which further exacerbated damage to dopaminergic neurons (Sarafian et al., 2017)
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Rotation breaks are standard practitioner practice not based on clinical data, but align with the general principle of avoiding continuous peptide exposure
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