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"Recent data published by Kaiser in June or July of this year showed that most people aren't staying on for even a year, whether due to insurance constraints or self selection

Furthermore, the weight loss induced by tirzepatide appears to be primarily due to a greater reduction in fat mass compared to metabolically active lean mass, resulting in a favorable redistribution of abdominal ectopic adipose tissue and a marked reduction in waist circumference and intrahepatic fat [54]

The glucagon component is the distinguishing addition: glucagon receptor activation increases energy expenditure and promotes hepatic fat mobilization

Dietary Supplementation with Glycine Enhances Intestinal Mucosal Integrity and Ameliorates Inflammation in C57BL/6J Mice with High-Fat Diet-Induced Obesity Coppola L., et al (1992)