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Lixisenatide ameliorates cerebral ischemia-reperfusion injury via glp-1 receptor dependent/independent pathways

Natural approaches, foods, and supplements can mimic and activate glucagon-like peptide-1 function, also known as GLP-1 agonists

doi: 10.1016/j.bpj.2013.11.024 37 LiaoDHuangYLiuDZhangHShiXLiXet al

In the U.S., about 6% of adults currently use GLP-1s, and 12% have used them in the past (2024 data) (Mozafariun 2025)

However, direct evidence linking post-GLP-1RA rebound to renewed ovulatory dysfunction, shortened fertile-window durability, or worsened pregnancy outcomes in PCOS is still lacking