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Tirzepatide is a dual receptor agonist that works on the following receptors: Glucagon-like peptide-1 (GLP-1) receptor: This receptor is involved in regulating blood sugar levels by stimulating insulin secretion and inhibiting glucagon release
Other studies have evaluated cellular signaling pathways linked to tissue remodeling and cytoskeletal organization
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Treatment with GLP1RA also increased the expression and the activity of ACE2 in organs like lungs (20, 72), heart (73, 74), and liver (75), restoring the ACE/ACE2 balance, which is impaired in kidney disease (76), diabetes mellitus (20), and cardiac fibrosis (73)
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