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Additionally, semaglutide acts on appetite-regulating centers in the hypothalamus, promoting satiety and reducing caloric intake, which contributes to weight loss
SURMOUNT-1 trial data showed mean weight reductions of 15.0% (5mg), 19.5% (10mg), and 20.9% (15mg) at 72 weeks, compared to 3.1% with placebo
Most of it resolves as the dose titrates
Plan for at least a year of medication plus a clear exit strategy
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