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10.3748/wjg.v23.i47.8437 26 opiA.Antoine-BallyS.Gimnez-AndrsM.La Torre GarayC.AntonnyB.ManniM

Abruptly discontinuing GLP-1 receptor agonists can cause rebound appetite, weight regain averaging 20-30% of lost weight in 6 months, and metabolic adaptation that makes future weight loss harder

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The visceral fat deposition was also found to be reduced, along with decreased plaque macrophages and smaller aortic plaques [56]

Notably, YEATS domain-containing reader proteins release RNA polymerase II from pausing states, enabling efficient transcription elongation-critical for rapid-response genes such as immediate-early genes