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Model Selection: Choose appropriate experimental systems: In vitro: Pituitary cell cultures, somatotroph cell lines Ex vivo: Pituitary tissue explants, hypothalamic-pituitary preparations In vivo: Age-matched animal models with appropriate controls 6

Conceptual confluence: the kynurenine pathway as a common target for ketamine and the convergence of the inflammation and glutamate hypotheses of depression

Polaska et al., 2024)

So DiMarchi started creating drugs that targeted both GLP-1 and glucagon receptors

Previous studies found that even major life events, a diabetes diagnosis, job loss, childbirth, produce only modest and short-lived changes in diet