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Moreover, some mechanisms worsen cardiovascular risk profile despite improving liver health, which appears incompatible with long-term use in patients with increased cardiovascular risk
References Desai SR, Khanna R
Sparsentan in patients with IgA nephropathy: a prespecified interim analysis from a randomised, double-blind, active-controlled clinical trial
97 mTORC1 functions as a major suppressor of lipophagy, and its inhibition restores autophagic flux and improves hepatic lipid handling
M.FujikawaT.LeeS.LordC
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