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The conformational flexibility of TM11 appears to be linked with substrate recognition, with R471 (responsible for carnitine coordination) located near the midpoint of this helix, between the two segments that bend during the transition between inward-facing and occluded conformations

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Of note, the prevalence of HF varied across these trials from 9% to 24%, and HF events were considered a secondary endpoint

By contrast, Aw et al

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