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18 GST can induce cellular apoptosis in the setting of cellular stress by activating MAPK, MKK4, downstream JNK-signal components, and p38 kinase

These findings are exciting because they suggest GLP-1 receptor agonists could have broader kidney-protective effects than initially thought, said the papers first author, Jefferson Triozzi, MD, MSCI, instructor in Medicine in the Division of Nephrology and Hypertension at VUMC

It analyzes pathway-level variants (GIPR (rs1800437), FTO (rs9939609), and MC4R (rs17782313)) that relate to the biology involved, offering context for a conversation with your provider rather than a prediction

doi: 10.1136/svn-2018000205 39 GgotekASkrzydlewskaE

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