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Exercise stimulates the release of myokines, anti-inflammatory molecules produced by working muscles, including interleukin-6 and irisin

Negro R, Greco G, Mangieri T, Pezzarossa A, Dazzi D, Hassan H

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However, this review also critically evaluates alternative explanations for the translational gap, including limited central nervous system penetration, insufficient pharmacodynamic target engagement, a mismatch between the drugs metabolic mechanisms and the amyloid-driven pathology of established AD, and the inherent limitations of preclinical models