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A preclinical pilot study in human patients with chronic pain episodes found, that DSIP significantly reduced pain perception, also improved mood by reduction of depressive states, and that it may potentially be of interest for research into physiological addiction on pain medications, as it was observed to reduce withdrawal symptoms that occurs after discontinuation of long-term analgesic treatment

While these are animal studies, they suggest that GHK-Cu may have broad neurological effects that contribute to overall wellbeing during the sometimes emotionally turbulent post-weight-loss period

For mild TBI, a double-blinded, placebo-controlled randomized phase II study found that the cerebrolysin group showed significantly greater cognitive improvement than placebo by week 12

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