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Werners syndrome is a type of condition, in which patients undergoing premature aging
K63-linked ubiquitination, which typically regulates signaling, DNA repair, and autophagy rather than degradation, is frequently altered in PD, AD, and ALS
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363,364 Similarly, GRP78 upregulation is detected in ALS spinal motor neurons, and region-specific UPR markers such as GRP58 and CHOP are found in prion diseases and HD, respectively
References 1 Wu, G., Fang, Y.-Z., Yang, S., Lupton, J
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