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Problematic chronic inflammation: Sustained inflammation (lasting weeks to months) degrades healthy tissue through proteolytic enzymes, reactive oxygen species, inflammatory cytokines (IL-1, TNF-)
Appetite and food reward 3-arm Phase 1 tirzepatide vs liraglutide 3.0 mg vs placebo: measured lunch intake fell 524.6 kcal vs placebo by week 3 (about 72% of that difference remained at week 6), with craving and hedonic-hunger reductions exceeding liraglutide
PMID 4980931
Resting astrocytes exposed to inflammatory stimuli initially adopt a transient neuroprotective state before transitioning into a sustained neurotoxic state
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