labial melanotic macule on lip

labial melanotic macule on lip 40 F. 4 mm dark brown lower lip. Diagnosis? Digital slide: https://kikoxp.com/posts/8019. Answer ✓ https://www.youtube.com/watch?v=O2yi2ir0Ubg #pathology #pathologists #pathTwitter #dermpath #dermatology #dermatologia #dermtwitter Labial Melanotic Macule On Lip

Name: labial melanotic macule on lip 40 F. 4 mm dark brown lower lip. Diagnosis? Digital slide: https://kikoxp.com/posts/8019. Answer ✓ https://www.youtube.com/watch?v=O2yi2ir0Ubg #pathology #pathologists #pathTwitter #dermpath #dermatology #dermatologia #dermtwitter Labial Melanotic Macule On Lip
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Description

The glucose-dependent increase and oscillations in intracellular Ca 2+ concentration associated with the mechanism of GSIS can stimulate mitochondrial generation of reactive oxygen species (ROS), whereas Ca 2+ , via protein kinase C activation, may enhance NADPH oxidase (NOX)-dependent generation of ROS [911]