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Semaglutide's 31-amino-acid framework maintains 94% homology to native GLP-1 while incorporating the Aib8 substitution, Lys26 C18 fatty acid conjugation, and Arg34 substitution that confer its extended half-life, DPP-4 resistance, and optimal albumin binding

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Due to their unique physicochemical properties and enhanced bioavailability, these materials hold tremendous potential to revolutionize ocular therapeutics