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These medications slow gastric emptying, reduce hunger signals, and improve insulin sensitivity

The concept draws from hormesis, a biological phenomenon where low-dose exposure to a substance produces beneficial effects while higher doses might produce neutral or even counterproductive outcomes

Effect of semaglutide on major cardiovascular events [PMID: 38237952] Laboratory literature summary: Effect of semaglutide on major cardiovascular events

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However, the suitability of current in vitro models, including those based on ARPE-19 cells, for accurately recapitulating RPE physiology in the context of diabetes warrants further optimization