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NPC1L1 is also highly expressed in human liver
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however, the very short half-life of endogenous GLP-1 (12 minutes) has limited its therapeutic use
A 2026 UK review of standardised EGb 761 , the Laws 2012 healthy-adult meta-analysis showing no effect, the null GEM and GuidAge trials, the modest mild-dementia benefit, dosing and the bleeding risk versus Dihexas unproven HGF/c-Met synaptogenesis and the c-Met concern
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