They are not recommended in those with personal or family history of multiple endocrine neoplasia 2A, multiple endocrine neoplasia 2B, or medullary thyroid cancer due to concern for long-term thyroid effects.3 Side Effects and their Implications in the ED Gastrointestinal Side effects Mild gastrointestinal side effects are most common with patients experiencing nausea (25-40%), vomiting, diarrhoea, or constipation.3,4 Rarer, more serious presentations include pancreatitis, bowel obstruction, gallbladder disease, which should be actively managed in the ED.3,5 Hypersensitivity reaction These reactions are commonly associated with self-limiting or antihistaminic responsive pruritic rash
Each of GHK-Cu, BPC-157 and TB-500 has its own separate body of published non-clinical literature, set out on each constituent product page
503A pharmacies are state-licensed and dispense patient-specific prescriptions, but they can only compound from FDA-approved drug components or substances on an FDA-evaluated bulk substances list
Whilst there is no official contraindication to taking these medications together, several clinical considerations require careful assessment
doi: 10.1007/s40256-024-00706-9 19 KosiborodMNAbildstrmSZBorlaugBAButlerJRasmussenSDaviesMet al