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Patients on Tirzepatide 15 mg weekly lost an average of 20.9% or 48.6 lb of their body weight after 72 weeks in the Zepbound Study 1 (NCT04184622) compared to placebo patients who lost an average of 3.1% or 7.2 lb

Importantly, controlling inflammation is believed to contribute in the prevention of cardiovascular diseases (123)

The pre-filled pen provides a measured dose each week, and the included four needles allow safe and easy injections into the skin (subcutaneous), usually in the abdomen, thigh or upper arm

When coupled to -arrestins, GPCRs are desensitized by abrogated coupling to G proteins and trafficked away from the cell surface, destined for either re-sensitization following their recycling back to the plasma membrane, or for final signal termination resulting from their degradation in lysosomes (McCorvy et al., 2017)

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