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The dosage was considerably lower in this trial (800 mg vs 30 mg/kg), which may account for the inability of NAC to affect glutathione repletion

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While the regulation of MTHFR activity is closely controlled by SAM at C-terminal regulatory domain, more studies indicated that the human MTHFR enzyme activity is also regulated by multiple phosphorylated sites on a serine-rich N-terminal extension region 20

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