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Integrated multi-omics approaches including transcriptomics, genomics, proteomics, metabolomics, and phenomics are transforming our understanding of resilience by revealing interactions among genes, proteins, and metabolites (Yang et al
Critically, therapeutic targeting of the gut-muscle axis reduces morbidity and mortality associated with muscle dysfunction in the elderly 14 , positioning it as a key research focus for deciphering the pathophysiology of obesity-induced muscle atrophy
GLP-1 receptor signalling promotes beta-cell glucose metabolism via mTOR-dependent HIF-1alpha activation
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