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Current Opinion in Investigational Drugs

Tesofensine at doses of 0.25 mg, 0.5 mg, and 1.0 mg led to average weight losses of 4.5%, 9.2%, and 10.6%, respectively, which were significantly higher than the weight loss achieved with the diet and placebo alone

Studies conducted on Nrf2 knockout mice have shown certain changes in the lens, including disruptions in cortical cell architecture, abnormal presence of nuclei in deeper lens regions, and ectopic nuclei in the posterior region

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