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The ferroptosis inhibitor liproxstatin-1 ameliorates K/BxN serum-transfer-induced arthritis in mice, accompanied by increased M2 macrophage proportions [127]
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However, many of these drugs were associated with unexpected adverse effects, such as nausea, aversion, valvular heart disease, and even suicidal tendencies, leading to the discontinuation of most of their development
1f), supporting changes in mitochondrial morphology and network formation
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