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Clayton Frenzel stresses with every surgical patient

Discontinue use and seek medical advice if you experience severe irritation, blistering, or a widespread rash

If these measures do not improve sleep, a doctor may advise cognitive behavioral therapy (CBT) and over-the-counter (OTC) or prescription sleep medications

For example, in a study by Mikhalkova et al

SGLT2-i Initiation and Insulin De-Escalation In a retrospective cohort study by Champion et al., initiation of SGLT2-ioften in combination with metformin and/or a GLP-1 receptor agonistled to significant reductions in both insulin dose and overbasalization rates