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However, its clinical application has been limited by dose-dependent gastrointestinal toxicity observed in later phase I and II clinical trials

doi:10.1016/j.amjmed.2009.03.015 Kooy A et al (2009): Long-term effects of metformin on metabolism and microvascular and macrovascular disease in patients with type 2 diabetes mellitus

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So compounding pharmacies started making their own version of the medication

These chemicals may impede ferroptosis, an iron-dependent mode of cellular demise, and provide tailored treatment by scavenging reactive oxygen species and averting lipid peroxidation in tumour microenvironments