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Here are some scenarios where B12 injections might be particularly beneficial: Vitamin B12 Deficiency : The most clear-cut candidates for B12 shots are those diagnosed with a B12 deficiency, which can cause symptoms like fatigue, weakness, constipation, loss of appetite, weight loss, and neurological changes such as numbness and tingling in the hands and feet

Intravenous (IV) use is less common and only done in clinical settings