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Considering that malignant cells need iron for proliferation and that TFR was demonstrated to be expressed on the surface of AML cells, it was tested if inhibition of the TFR may lead to an antiproliferative effect due to a decreased iron import

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J Bioenerg Biomembr 36: 187193 Kojer K, Bien M, Gangel H, Morgan B, Dick TP, Riemer J (2012) Glutathione redox potential in the mitochondrial intermembrane space is linked to the cytosol and impacts the Mia40 redox state