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No specific contraindication exists for single-kidney patients, but specialist nephrology input is recommended for those on dialysis or with unstable renal function
Besides HbA1c and weight reduction, the criteria for initiating a GLP-1 RA with proven CV benefit should include an estimation of the patient's CV risk
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Other important side effects include gallbladder disease (cholelithiasis, cholecystitis), and potential worsening of diabetic retinopathy (particularly with rapid HbA1c reduction on semaglutide)
8-12 Specifically, the addition of a GLP-1 RA may also confer the added benefit of slowing the progression of albuminuria
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