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Van Goethem S, Matheeussen V, Joossens J, Lambeir AM, Chen X, De Meester I, et al

Serious side effects can also occur when taking Contrave, including the following: Suicidal thoughts or actions Depression, anxiety, agitation, or restlessness Panic attacks Mania Mood changes Allergic reactions: rash, itching, hives, fever, swollen lymph glands, painful mouth sores, swelling of the lip or tongue, chest pain, trouble breathing Increased blood pressure or heart rate Liver damage or hepatitis Visual problems (angle-closure glaucoma) Hypoglycemia Seizures Contrave has a boxed warning for suicidal thoughts and behaviors

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Peptides like PT-141 act through the central nervous system on libido and desire itself, not on blood flow