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JCI Insight 2020;5(17): 10.1172/jci.insight.140532)
Standard protocol: 250 mcg once/twice daily, 48 week cycles
The mechanism appears to involve increased serotonin synthesis in substantia nigra (both compacta and reticulata), a regional pattern unlike any existing antidepressant drug, plus potential dopaminergic contributions given the nigrostriatal location
Targeting RTK signaling pathways in cancer
B12 injections are a direct and efficient way to restore optimal levels, especially when supplements or diet changes havent made a difference
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