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Yes, certain medications promote weight gain and can counteract GLP-1 effects, including antipsychotics (olanzapine, clozapine), mood stabilizers (valproate, lithium), some antidepressants (mirtazapine, paroxetine), corticosteroids, and diabetes medications like insulin or sulfonylureas
It is not a drug, supplement, or medical device, and it must not be administered to humans or animals
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Degradation assay Cells were treated in serum-free medium plus 11 mM glucose agonist (100 nM) before lysis (20 mM Tris base, 150 mM NaCl, 1 mM EDTA, 1 mM EGTA, 0.5% Triton X-100 plus complete mini EDTA-free protease inhibitor (Roche)), addition of urea sample buffer (100 mM Tris-HCl pH 6.8, 2.5% SDS, 4 M urea, 100 mM DTT, 0.05% bromophenol blue), 10 min incubation at 37 C and immunoblotting
Obesity is a disease that does not discriminate, Dr le Roux continues
