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The flagship trial STEP-1 (published in NEJM , 2021) found a mean weight reduction of ~14.9% of body weight with semaglutide 2.4 mg vs ~2.4% with placebo over 68 weeks ( [12] )
The usual recommended starting dose of metformin immediate-release tablets in adults with normal kidney function is 500 mg by mouth twice a day, or 850 mg once daily
In particular, tell your provider if you have or have a past history of: Type 1 or type 2 diabetes Thyroid cancer Pancreatitis Kidney disease Diabetic retinopathy Tell your provider if you are pregnant, planning to become pregnant, or breastfeeding
Semaglutide is not recommended during pregnancy, but the medication itself does not cause infertility
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