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96 participants were randomly assigned to groups of 6 multiple-ascending doses of once-weekly subcutaneous cagrilintide (final doses of 0.16, 0.30, 0.60, 1.2, 2.4, and 4.5 mg) in combination with once-weekly subcutaneous semaglutide 2.4 mg or semaglutide 2.4 mg with placebo for 20 weeks
Evidence for these combinations remains limited to case reports and small case series, but interest is growing
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The energy boost from the B12 component is often felt within 24 to 72 hours after the injection and typically lasts through the week
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