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For split-dose protocols (250 mcg twice daily), take the second dose at least 3 hours after your last meal

doi: 10.3389/fchem.2025.1536858 Received 29 November 2024 Accepted 27 January 2025 Published 19 March 2025 Volume 13 - 2025 Edited by Federica Aureli, National Institute of Health (ISS), Italy Reviewed by Eric Deconinck, Sciensano (Belgium), Belgium Maria Cristina Gaudiano, National Institute of Health (ISS), Italy Updates Copyright 2025 Blazewicz, Poplawska, Daniszewska, Piorunska and Karynski

Unreconstituted powder: Sealed lyophilized vials can handle room temperature for up to 24 months in most formulations

Protein intake of 1.6-2.0 g/kg body weight during a caloric deficit is supported by extensive weight loss research for lean mass preservation (Wycherley et al., 2012)

Symptoms of Vitamin B12 Deficiency A lack of Vitamin B12 (also called cobalamin ) can affect many systems in your body, from blood health to nerve function