Alcohol Several studies investigating exendin-4, liraglutide, dulaglutide and semaglutide in rats and mice found a decrease in alcohol use, which was mediated by mesolimbic dopamine pathways involving the nucleus accumbens, the ventral tegmental area and the ventral hippocampus, the dorso-lateral septum, and the nucleus of the solitary tract 59,60,61,63,64,65,66,67,68,69,72,74,75,76,77,79,80,81,82,106
This flexibility is useful for specialized research applications that require specific compound characteristics or delivery formats
What does a GLP-1 Modulator do
In preclinical and clinical settings, amylin has been combined with several other compounds with weight regulatory abilities to elicit beneficial effects on body weight
In the SUSTAIN program, 83 patients (1.4%) treated with semaglutide developed a gallbladder event, compared with 39 patients (1.9%) in the placebo group ( versus 0.1% with placebo), while the risk of cholecystitis was similar (data derived from the summary of product characteristics (SmPC) (87), as the manuscripts did not describe these data)