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Frontiers in Pharmacology, 15 , 1416985
Substituting the C-terminal region of GIPR with that of GLP-1 had no detectable impact on GIP-stimulated arrestin3 recruitment to GIPR using either BRET pair (Figures 3A, C
According to clinical trials, prescription GLP-1 medications typically lead to 518% weight loss, while studies of high-dose tirzepatide combined with intensive lifestyle support have reported reductions of up to ~25%
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