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Insulin and sulfonylureas: GLP-1 and amylin both reduce postprandial glucagon and slow gastric emptying adding either to insulin or sulfonylureas increases hypoglycemia risk

GLP-1 medications carry risks including nausea, pancreatitis, gallbladder disease, kidney injury, and a boxed warning for thyroid C-cell tumors

And that's completely normal

The DMPI is dedicated to understanding the molecular makeup of obesity and type 2 diabetes and the cardiovascular disease that often accompanies them, and to developing early-detection strategies and new treatments