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In fertility and early embryonic development studies, male and female rats were administered twice weekly subcutaneous doses of 0.5, 1.5, or 3 mg/kg (0.3-, 1-, and 2-fold and 0.3-, 0.9-, and 2-fold, respectively, the MRHD of 15 mg once weekly based on AUC)
Think about quality assurance requirements
The risk increases with each exposure
This can lead to health issues like megaloblastic anemia
Moreover, the amount of B12 in the liver reflects its metabolic requirements, not storage
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