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They contain a synthetic version of the GLP-1 hormone that is produced in the small intestine and colon to help regulate insulin levels in response to food intake
Some key points about these medications include: Semaglutide is the active ingredient in both Ozempic (used for diabetes and off-label for weight loss) and Wegovy (used for weight loss)
Weight loss may alter relationship dynamics, and partners may respond differently to physical changes
This review has deliberately distinguished failed biology from failed pharmacology, emphasizing that genuine on-target toxicity, repeated lack of efficacy in well-designed human studies, or insurmountable technical barriers justify abandonment
PMCID: PMC5148911
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