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Most peptides degrade in the digestive system, making injectable administration standard

doi:10.1038/ncb1807, PMID: 19029908 Kizhakkayil J, Thayyullathil F, Chathoth S, Hago A, Patel M, Galadari S (2012) Glutathione regulates caspase-dependent ceramide production and curcumin-induced apoptosis in human leukemic cells

For preclinical tissue models, stronger evidence would require standardized injury models, blinded outcome assessment, histological confirmation, functional endpoints, and comparison against appropriate positive and negative controls

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