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Addressing Tolerability Issues Gastrointestinal adverse effects (nausea, vomiting, diarrhea, constipation) are the most common reasons for discontinuation
Polymeric nanoparticles, especially those derived from PLGA (poly(lactic-co-glycolic acid)), have been used to prepare long-acting formulations of GLP-1 that can extend the release period to weeks with a single dose, reducing injection frequency and improving patient adherence [33]
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Still, it can be helpful to know whether the redness, rash, or pain youre experiencing is normal and expected or if its something you need to discuss with your healthcare provider
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