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As with other incretin-based therapies, the most commonly reported adverse effects of retatrutide in Phase 2 trials were gastrointestinal in nature (Jastreboff et al., NEJM , 2023)
The standard dietary reference intake for protein in adults is 0.8 grams per kilogram of body weight per day, but this baseline recommendation may be insufficient for individuals undergoing significant weight loss on GLP-1 medications
Evoke phase 3 trials did not demonstrate a statistically significant reduction in Alzheimer's disease progression [Press release]
Interestingly, compared with the model group, the TC and TG contents of the Lira group had a decreasing trend but the difference was not statistically significant
I haven't seen anybody with bad pancreatitis, but that certainly will happen
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