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Summary: The retatrutide phase 2 NEJM trial reported mean body weight reductions of up to approximately 24.2% at 48 weeks with the 12 mg dose in adults with obesity without type 2 diabetes
Starting doses are intentionally low to minimize side effects, so stronger appetite suppression often develops as dosing progresses
Given the complexity of these peptides, bioequivalence cannot rely solely on pharmacokinetic data
The direct regulation of GLP-1 on insulin expression is significant for type 2 diabetes (T2D) patients with simple glucose tolerance but normal insulin secretion ( 2 Peptide-based GLP-1 derivatives and small molecule compounds of GLP-1RA There are two main categories of GLP-1 receptor agonists, small molecule compounds and peptide-based GLP-1 derivatives as shown in Figure 1 , including exenatide, liraglutide, dulaglutide, etc
The compound is highly specific for GLP-1R, as it is unable to activate the closely related human receptors for glucagon, glucagon-like peptide-2 (GLP-2) and secretin
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